New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745.

ABSTRACT: As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 μM, respectively.

SUBMITTER: Zhang D 

PROVIDER: S-EPMC6163353 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature