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New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745.

ABSTRACT: As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 ?M, respectively.

SUBMITTER: Zhang D 

PROVIDER: S-EPMC6163353 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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New Antibacterial Bagremycins F and G from the Marine-Derived <i>Streptomyces</i> sp. ZZ745.

Zhang Di D   Shu Chenyan C   Lian Xiaoyuan X   Zhang Zhizhen Z  

Marine drugs 20180912 9

As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (<b>1</b>) and G (<b>2</b>), were isolated from a marine actinomycete <i>Streptomyces</i> sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (<b>1</b>) and G (<b>2</b>) showed antibacterial activity against <i>Escherichia  ...[more]

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