Warfarin: The End or the End of One Size Fits All Therapy?

ABSTRACT: Oral anticoagulants are required for both treatment and prophylaxis in many different diseases. Clinicians and patients now have a choice of oral anticoagulants, including the vitamin K antagonists (of which warfarin is the most widely used and is used as the exemplar in this paper), and direct oral anticoagulants (DOACs: dabigatran, apixaban, rivaroxaban, and edoxaban). This paper explores the recent advances and controversies in oral anticoagulation. While some commentators may favour a complete switchover to DOACs, this paper argues that warfarin still has a place in therapy, and a stratified approach that enables the correct choice of both drug and dose would improve both patient outcomes and affordability.

SUBMITTER: Pirmohamed M 

PROVIDER: S-EPMC6163581 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature