Individualized Transcriptional Resolution of Complicated Malaria in a Colombian Study.

ABSTRACT: To evaluate whether recovery from complicated malaria follows a common trajectory in terms of immunological mechanism or, rather, is highly individualized for each patient, we performed longitudinal gene expression profiling of whole blood. RNA sequencing (RNAseq) was performed on blood samples obtained from eight patients on four consecutive days between hospital admission and discharge. Six patients were infected with Plasmodium falciparum, and two with Plasmodium vivax; one patient was a pregnant woman infected with P. falciparum, who was hospitalized for several weeks. The characterization of blood transcript modules (BTM) and blood informative transcripts (BIT) revealed that patients' responses showed little commonality, being dominated by the balance of gene activity relating to lymp

SUBMITTER: Rojas-Pena ML 

PROVIDER: S-EPMC6163772 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature