Tenogenic Properties of Mesenchymal Progenitor Cells Are Compromised in an Inflammatory Environment.

ABSTRACT: Transplantation of multipotent mesenchymal progenitor cells is a valuable option for treating tendon disease. Tenogenic differentiation leading to cell replacement and subsequent matrix modulation may contribute to the regenerative effects of these cells, but it is unclear whether this occurs in the inflammatory environment of acute tendon disease. Equine adipose-derived stromal cells (ASC) were cultured as monolayers or on decellularized tendon scaffolds in static or dynamic conditions, the latter represented by cyclic stretching. The impact of different inflammatory conditions, as represented by supplementation with interleukin-1β and/or tumor necrosis factor-α or by co-culture with allogeneic peripheral blood leukocytes, on ASC functional properties was investigated. High cytokine conce

SUBMITTER: Brandt L 

PROVIDER: S-EPMC6163784 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature