Computational Study of Sensitivity Enhancement in Surface Plasmon Resonance (SPR) Biosensors by Using the Inclusion of the Core-Shell for Biomaterial Sample Detection.

ABSTRACT: A theoretical analysis and computational study of biomaterial sample detection with surface plasmon resonance (SPR) phenomenon spectroscopy are presented in this work with the objective of achieving more sensitive detection. In this paper, a Fe₃O₄@Au core-shell, a nanocomposite spherical nanoparticle consisting of a spherical Fe₃O₄ core covered by an Au shell, was used as an active material for biomaterial sample detection, such as for blood plasma, haemoglobin (Hb) cytoplasm and lecithin, with a wavelength of 632.8 nm. We present the detection amplification technique through an attenuated total reflection (ATR) spectrum in the Kretschmann configuration. The system consists of a four-layer material, i.e., prism/Ag/Fe₃O₄@Au + biomaterial sample/air. The effective permittivity determination

SUBMITTER: Widayanti 

PROVIDER: S-EPMC6164099 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature