In vivo quantification of rolling and adhered leukocytes in human sepsis.

ABSTRACT:

Background

The use of in vivo videomicroscopy at the bedside has demonstrated microcirculatory flow disturbances in sepsis. The ability of in vivo videomicroscopy to detect changes in the prevalence of rolling and adhered leukocytes that occur in sepsis is not well-described in humans. We sought to (1) develop methodology for accessing and quantifying sublingual leukocyte rolling and adherence with sidestream dark field (SDF) imaging; (2) compare the number of rolling and adhered leukocytes between patients with septic shock and non-infected controls; and (3) compare the number of rolling and adhered leukocytes between survivors and non-survivors of septic shock.

Methods

We included adult (age > 18 years) patients in the emergency department presenting with septic shock pros

SUBMITTER: Fabian-Jessing BK 

PROVIDER: S-EPMC6164176 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature