Evaluation of Active Brown Adipose Tissue by the Use of Hyperpolarized [1-¹³C]Pyruvate MRI in Mice.

ABSTRACT: The capacity to increase energy expenditure makes brown adipose tissue (BAT) a putative target for treatment of metabolic diseases such as obesity. Presently, investigation of BAT in vivo is mainly performed by fluoro-d-glucose positron emission tomography (FDG PET)/CT. However, non-radioactive methods that add information on, for example, substrate metabolism are warranted. Thus, the aim of this study was to evaluate the potential of hyperpolarized [1-¹³C]pyruvate Magnetic Resonance Imaging (HP-MRI) to determine BAT activity in mice following chronic cold exposure. Cold (6 °C) and thermo-neutral (30 °C) acclimated mice were scanned with HP-MRI for assessment of the interscapular BAT (iBAT) activity. Comparable mice were scanned with the conventional method FDG PET/MRI. Finally,

SUBMITTER: Riis-Vestergaard MJ 

PROVIDER: S-EPMC6164296 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature