Lower-Sized Chitosan Nanocapsules for Transcutaneous Antigen Delivery.

ABSTRACT: Transcutaneous vaccination has several advantages including having a noninvasive route and needle-free administration; nonetheless developing an effective transdermal formulation has not been an easy task because skin physiology, particularly the stratum corneum, does not allow antigen penetration. Size is a crucial parameter for successful active molecule administration through the skin. Here we report a new core-shell structure rationally developed for transcutaneous antigen delivery. The resulting multifunctional carrier has an oily core with immune adjuvant properties and a polymeric corona made of chitosan. This system has a size of around 100 nm and a positive zeta potential. The new formulation is stable in storage and physiological conditions. Ovalbumin (OVA) was used as the antige

SUBMITTER: Bussio JI 

PROVIDER: S-EPMC6164329 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature