Associations between Flavonoid Intakes and Gut Microbiota in a Group of Adults with Cystic Fibrosis.

ABSTRACT: Dietary flavonoid intakes can influence gut microbiota (GM), which in turn can affect immune function and host metabolism, both vital considerations in cystic fibrosis (CF) management. In CF, GM may be altered and link to CF respiratory events. This study explored the relationship between flavonoid intakes and GM in free-living adults with CF. Associations between the overall GM variations (unweighted and weighted UniFrac distances between pyrosequencing results of bacterial 16-ss rDNA from frozen faecal samples of sixteen CF adults) and standardised dietary flavonoid intakes (a validated flavonoid-specific food frequency questionnaire) were analysed using adonis tests. Flavonoid intakes that were significant at a false discovery rate (FDR) < 0.3 were subjected to Spearman correlation test

SUBMITTER: Li L 

PROVIDER: S-EPMC6164979 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature