Valproic Acid Downregulates Cytokine Expression in Human Macrophages Infected with Dengue Virus.

ABSTRACT: Natural infection with dengue virus (DENV) induces an increase in the production of cytokines that play an important role in disease pathogenesis. Despite numerous scientific studies, there are still no commercially available disease-specific therapeutics. Previous evidence shows that inhibiting histone deacetylase enzymes (HDACs) regulates the immune response in several inflammatory disease models. The aim of the current study was to evaluate the effect of HDAC inhibition in the production of inflammatory cytokines in human monocyte-derived macrophages infected with DENV serotype 2 (DENV-2). To this end, human monocyte-derived macrophages (MDMs) were treated with valproic acid (VPA) before or after infection and the inflammatory cytokine concentration was quantified by flow cytometry. We

SUBMITTER: Delgado FG 

PROVIDER: S-EPMC6165057 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature