Weanling Offspring of Dams Maintained on Serine-Deficient Diet Are Vulnerable to Oxidative Stress.

ABSTRACT: Serine plays an important role in the antioxidant defense system. However, the effects of maternal serine deficiency on the antioxidant ability of weanling offspring have not been reported. In the present study, we investigated the oxidative status of offspring of dams that are maintained on serine-deficient diet and subjected to diquat challenge. Individual pregnant animals were randomly divided into two dietary groups, namely, the control diet group and the serine- and glycine-deficient diet group. Samples were collected from weanling offspring at the age of 3 weeks after diquat challenge. Our results showed that maternal serine deficiency did not affect the levels of antioxidant enzymes and reactive oxygen species, as well as the expression of cellular and mitochondrial stress markers (

SUBMITTER: He L 

PROVIDER: S-EPMC6165615 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature