Model-based detection and analysis of introgressed Neanderthal ancestry in modern humans.

ABSTRACT: Genetic evidence has revealed that the ancestors of modern human populations outside Africa and their hominin sister groups, notably Neanderthals, exchanged genetic material in the past. The distribution of these introgressed sequence tracts along modern-day human genomes provides insight into the selective forces acting on them and the role of introgression in the evolutionary history of hominins. Studying introgression patterns on the X-chromosome is of particular interest, as sex chromosomes are thought to play a special role in speciation. Recent studies have developed methods to localize introgressed ancestries, reporting long regions that are depleted of Neanderthal introgression and enriched in genes, suggesting negative selection against the Neanderthal variants. On the other hand,

SUBMITTER: Steinrucken M 

PROVIDER: S-EPMC6165692 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature