Haemodynamic or metabolic stimulation tests to reveal the renal functional response: requiem or revival?

ABSTRACT: Renal stimulation tests document the dynamic response of the glomerular filtration rate (GFR) after a single or a combination of stimuli, such as an intravenous infusion of dopamine or amino acids or an oral protein meal. The increment of the GFR above the unstimulated state has formerly been called the renal functional reserve (RFR). Although the concept of a renal reserve capacity has not withstood scientific scrutiny, the literature documenting renal stimulation merits renewed interest. An absent or a blunted response of the GFR after a stimulus indicates lost or diseased nephrons. This information is valuable in preventing, diagnosing and prognosticating acute kidney injury and pregnancy-related renal events as well as chronic kidney disease. However, before renal function testing is u

SUBMITTER: De Moor B 

PROVIDER: S-EPMC6165749 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature