CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth.

ABSTRACT: Tumor formation involves the acquisition of numerous capacities along the progression from a normal cell into a malignant cell, including limitless proliferation (immortalization) and anchorage-independent growth, a capacity that correlates extremely well with tumorigenesis. Great efforts have been made to uncover genes involved in tumor formation, but most genes identified participate in processes related to cell proliferation. Accordingly, therapies targeting these genes also affect the proliferation of normal cells. To identify potential targets for therapeutic intervention more specific to tumor cells, we looked for genes implicated in the acquisition of anchorage-independent growth and in vivo tumorigenesis capacity. A transcriptomic analysis identified CDCA7 as a candid

SUBMITTER: Jimenez-P R 

PROVIDER: S-EPMC6165795 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature