Increased right atrial volume measured with cardiac magnetic resonance is associated with worse clinical outcome in patients with pre-capillary pulmonary hypertension.

ABSTRACT:

Aims

Pre-capillary pulmonary hypertension (PH_pre-cap ) has a poor prognosis, especially when caused by pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc-PAH). Whether cardiac magnetic resonance (CMR)-based quantification of atrial volumes in PH_pre-cap is beneficial in risk assessment is unknown. The aims were to investigate if (i) atrial volumes using CMR are associated with death or lung transplantation in PH_pre-cap , (ii) atrial volumes differ among four unmatched major PH_pre-cap subgroups, and (iii) atrial volumes differ between SSc-PAH and idiopathic/familial PAH (IPAH/FPAH) when matched for pulmonary vascular resistance (PVR).

Methods and results

Seventy-five PH_pre-cap patients (57 ± 19 y

SUBMITTER: Bredfelt A 

PROVIDER: S-EPMC6165945 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature