Nicotine-Induced Conditional Place Preference Is Affected by Head Injury: Correlation with Dopamine Release in the Nucleus Accumbens Shell.

ABSTRACT:

Background

Traumatic brain injury is known to impact dopamine-mediated reward pathways, but the underlying mechanisms have not been fully established.

Methods

Nicotine-induced conditional place preference was used to study rats exposed to a 6-psi fluid percussion injury with and without prior exposure to nicotine. Preference was quantified as a score defined as (C1 - C2) / (C1 + C2), where C1 is time in the nicotine-paired compartment and C2 is time in the saline-paired compartment. Subsequent fast-scan cyclic voltammetry was used to analyze the impact of nicotine infusion on dopamine release in the shell portion of the nucleus accumbens. To further determine the influence of brain injury on nicotine withdrawal, nicotine infusion was administered to the rats after fluid perc

SUBMITTER: Chen YH 

PROVIDER: S-EPMC6165954 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature