GRK5 Is Associated with the Regulation of Methadone Dosage in Heroin Dependence.

ABSTRACT:

Background

There is no countable biomarker for opioid dependence treatment responses thus far. In this study, we recruited Taiwanese methadone maintenance treatment patients to search for genes involving the regulatory mechanisms of methadone dose by genome-wide association analyses.

Methods

A total of 344 Taiwanese methadone maintenance treatment patients were included in a genome-wide association study. The involvement of GRK5 in opioid dependence was then further confirmed by gene expression study on lymphoblastoid cell lines derived from 3 independent age- and gender-matched groups: methadone maintenance treatment patients, medication-free former heroin abusers, and normal controls.

Results

The results indicated that GRK5, the gene encoding an enzyme related to μ-

SUBMITTER: Wang SC 

PROVIDER: S-EPMC6165957 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature