Catecholaminergic Modulation of Conflict Control Depends on the Source of Conflicts.

ABSTRACT:

Background

To display goal-directed behavior, we must be able to resolve response conflicts that arise from processing various distractors. Such conflicts may be triggered by different kinds of distractor stimuli (e.g., priming and flanker stimuli), but it has remained largely unclear whether the functional and neurobiological underpinnings of both conflict types differ. We therefore investigated the functional relevance of the catecholamines dopamine and norepinephrine, which have been shown to increase the signal-to-noise ratio in neuronal processing and should therefore modulate response conflicts.

Methods

In a double-blind, randomized, placebo-controlled study design, we examined the effect of methylphenidate (0.5 mg/kg) on both flanker-induced and priming-induced respon

SUBMITTER: Bensmann W 

PROVIDER: S-EPMC6165959 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature