Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer.

ABSTRACT: Ovarian cancer (OC) is one of the most intractable diseases, exhibiting tremendous molecular heterogeneity and lacking reliable methods for screening, resulting in late diagnosis and widespread peritoneal dissemination. Menopausal estrogen replacement therapy is a well-recognized risk factor for OC, but little is known about how estrogen might contribute to this disease at the cellular level. This study identifies chemokine receptor CXCR7/ACKR3 as an estrogen-responsive gene, whose expression is markedly enhanced by estrogen through direct recruitment of ERα and transcriptional active histone modifications in OC cells. The gene encoding CXCR7 chemokine ligand I-TAC/CXCL11 was also upregulated by estrogen, resulting in Ser-118 phosphorylation, activation, and recruitment of estrogen recepto

SUBMITTER: Benhadjeba S 

PROVIDER: S-EPMC6165996 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature