Microarray expression profile of long non-coding RNAs in human lung adenocarcinoma.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) participate in many biological dynamics and play significant roles in gene regulation. LncRNA expression is altered in many cancers; however, the expressions and functions of lncRNA genes in lung adenocarcinoma (LAD) remain unknown.

Methods

LncRNA and messenger RNA (mRNA) expression in LAD without lymphatic metastasis versus paired adjacent non-tumor (ANT) lung tissues and LAD with versus without lymphatic metastasis were analyzed using Human LncRNA Arraystar V3.0. The expression levels of four downregulated and four upregulated lncRNAs were verified using quantitative real-time PCR in cells and tissue specimens.

Results

In this study, 949 lncRNAs and 681 mRNAs had differential expression in LAD without lymphatic metastasis co

SUBMITTER: Yang Z 

PROVIDER: S-EPMC6166069 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature