Tuning the endothelial response: differential release of exocytic cargos from Weibel-Palade bodies.

ABSTRACT: Essentials Endothelial activation initiates multiple processes, including hemostasis and inflammation. The molecules that contribute to these processes are co-stored in secretory granules. How can the cells control release of granule content to allow differentiated responses? Selected agonists recruit an exocytosis-linked actin ring to boost release of a subset of cargo.

Summary

Background Endothelial cells harbor specialized storage organelles, Weibel-Palade bodies (WPBs). Exocytosis of WPB content into the vascular lumen initiates primary hemostasis, mediated by von Willebrand factor (VWF), and inflammation, mediated by several proteins including P-selectin. During full fusion, secretion of this large hemostatic protein and smaller pro-inflammatory proteins are thought to be inext

SUBMITTER: Nightingale TD 

PROVIDER: S-EPMC6166140 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature