Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease.

ABSTRACT: BACKGROUND:Hypoxic-ischemic white matter brain injury commonly occurs in neonates with critical congenital heart disease. Recent work has shown that longer time to surgery is associated with increased risk for this injury. In this study we investigated changes in perinatal cerebral hemodynamics during the transition from fetal to neonatal circulation to ascertain mechanisms that might underlie this risk. METHODS:Neonates with either transposition of the great arteries (TGA) or hypoplastic left heart syndrome (HLHS) were recruited for preoperative noninvasive optical monitoring of cerebral oxygen saturation, cerebral oxygen extraction fraction, and cerebral blood flow using diffuse optical spectroscopy and diffuse correlation spectroscopy, 2 noninvasive optical techniques. Measurements were

SUBMITTER: Lynch JM 

PROVIDER: S-EPMC6166233 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature