Role of aberrant glycosylation enzymes in oral cancer progression.

ABSTRACT:

Background

Carcinogenesis, a multistep process involves sequential changes during neoplastic transformation. The various hallmarks of cancer aid in cell survival, proliferation, and dissemination. Aberrant glycosylation, a recently defined hallmark of cancer, is influenced by glycosylation enzymes during carcinogenesis. Therefore, the present study measured α-2,3 and α-2,6 sialyltransferase (ST), sialidase, and α-L-fucosidase activity in patients with oral precancerous conditions (OPC) and oral cancer patients.

Subjects

The study enrolled 100 oral cancer patients, 50 patients with OPC, 100 healthy controls, and 46 posttreatment follow-ups of oral cancer patients. Blood and saliva were collected from all the participants.

Materials and methods

Sialidase activity was me

SUBMITTER: Vajaria BN 

PROVIDER: S-EPMC6166416 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature