Clearance kinetics of the VGF-derived neuropeptide TLQP-21.

ABSTRACT: TLQP-21 is a multifunctional neuropeptide and a promising new medicinal target for cardiometabolic and neurological diseases. However, to date its clearance kinetics and plasma stability have not been studied. The presence of four arginine residues led us to hypothesize that its half-life is relatively short. Conversely, its biological activities led us to hypothesize that the peptide is still taken up by adipose tissues effectively. [¹²⁵I]TLQP-21 was i.v. administered in rats followed by chasing the plasma radioactivity and assessing tissue uptake. Plasma stability was measured using LC-MS. In vivo lipolysis was assessed by the palmitate rate of appearance.

Results

A small single i.v. dose of [¹²⁵I]TLQP-21 had a terminal half-life of 110 min with a terminal cl

SUBMITTER: Guo Z 

PROVIDER: S-EPMC6166661 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature