Long-term safety outcome of systemic immunosuppression in pig-to-nonhuman primate corneal xenotransplantation.

ABSTRACT:

Background

Safety concerns exist for corneal recipients under immunosuppression. We report long-term safety results of porcine corneal xenotransplantation under immunosuppression in nonhuman primates.

Methods

Systemic monitoring data from 49 Chinese rhesus macaques that received pig corneal transplant between 2009 and 2018 were retrospectively reviewed. The recipients were divided into 4 groups depending on the systemic immunosuppressants used: (a) conventional steroid group; costimulation blockade groups ([b] anti-CD154 antibody, [c] anti-CD40 antibody); and (d) commercially available immunosuppressants (anti-CD20 antibody, tacrolimus, basiliximab) group. We compared results of general condition monitoring; hematologic, biochemical, and electrolyte tests; and Rhesus Cytomeg

SUBMITTER: Choi SH 

PROVIDER: S-EPMC6166667 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature