Influenza A Virus Induces Autophagosomal Targeting of Ribosomal Proteins.

ABSTRACT: Seasonal epidemics of influenza A virus are a major cause of severe illness and are of high socio-economic relevance. For the design of effective antiviral therapies, a detailed knowledge of pathways perturbed by virus infection is critical. We performed comprehensive expression and organellar proteomics experiments to study the cellular consequences of influenza A virus infection using three human epithelial cell lines derived from human lung carcinomas: A549, Calu-1 and NCI-H1299. As a common response, the type I interferon pathway was up-regulated upon infection. Interestingly, influenza A virus infection led to numerous cell line-specific responses affecting both protein abundance as well as subcellular localization. In A549 cells, the vesicular compartment appeared expanded after viru

SUBMITTER: Becker AC 

PROVIDER: S-EPMC6166674 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature