Proteomic Delineation of the ArcA Regulon in Salmonella Typhimurium During Anaerobiosis.

ABSTRACT: Salmonella enterica serovar Typhimurium (S. Typhimurium) is one of the most used models for bacterial pathogenesis and successful infection requires its adaptation to the low oxygen environment in host gastrointestinal tracts. Central to this process is the Arc (aerobic respiratory control) two-component regulatory system that contains a sensor kinase ArcB and a response regulator ArcA. Nevertheless, a comprehensive profile of the ArcA regulon on the proteome level is still lacking in S. Typhimurium. Here we quantitatively profiled Salmonella proteome during anaerobiosis in an arcA-deleting mutant compared with its parental strain. In addition to known processes under its control, notably we found that ArcA represses ethanolamine util

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6166683 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature