Antibacterial and biodegradable tissue nano-adhesives for rapid wound closure.

ABSTRACT:

Background

Although various organic tissue adhesives designed to facilitate would healing are gaining popularity in diverse clinical applications, they present significant inherent limitations, such as rejection, infections, toxicity and/or excessive swelling. It is highly desirable to develop efficient, biocompatible and anti-bacterial tissue adhesives for skin wound healing.

Purpose

Inspired by the fact that inorganic nanoparticles can directly glue tissues through the "nanobridging effect", herein disulfide bond-bridged nanosilver-decorated mesoporous silica nanoparticles (Ag-MSNs) was constructed as an effective and safe tissue adhesive with antibacterial and degradable properties for wound closure and healing.

Materials and methods

Ag-MSNs was fabricated by contr

SUBMITTER: Lu MM 

PROVIDER: S-EPMC6166764 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature