Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury.

ABSTRACT: Recombinant tissue plasminogen activator (tPA) is a Food and Drug Administration-approved thrombolytic treatment for ischemic stroke. tPA is also naturally expressed in glial and neuronal cells of the brain, where it promotes axon outgrowth and synaptic plasticity. However, there are conflicting reports of harmful versus neuroprotective effects of tPA in acute brain injury models. Furthermore, its impact on white matter integrity in preclinical traumatic brain injury (TBI) has not been thoroughly explored, although white matter disruption is a better predictor of long-term clinical outcomes than focal lesion volumes. Here we show that the absence of endogenous tPA in knockout mice impedes long-term recovery of white matter and neurological function after TBI. tPA-knockout mice exhibited gr

SUBMITTER: Xia Y 

PROVIDER: S-EPMC6166834 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature