Ontology highlight
ABSTRACT:
SUBMITTER: Jelencic V
PROVIDER: S-EPMC6166863 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature immunology 20180917 10
The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating receptor NKG2D specifically set the activation threshold for the activating receptor NCR1 through a process that required the adaptor DAP12. As a result, NKGD2-deficient (Klrk1<sup>-/-</sup>) mice controlled t ...[more]