NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development.

ABSTRACT: The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating receptor NKG2D specifically set the activation threshold for the activating receptor NCR1 through a process that required the adaptor DAP12. As a result, NKGD2-deficient (Klrk1^-/-) mice controlled tumors and cytomegalovirus infection better than wild-type controls through the NCR1-induced production of the cytokine IFN-γ. Expression of NKG2D before the immature NK cell stage increased expression of the adaptor CD3ζ. Reduced expression of CD3ζ in Klrk1^-/- mice was associated with enh

SUBMITTER: Jelencic V 

PROVIDER: S-EPMC6166863 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature