STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper.

ABSTRACT: Preserving energy homeostasis in the presence of stressors such as proinflammatory cytokines and nutrient overload is crucial to maintaining normal cellular function. Six transmembrane epithelial antigen of the prostate 4 (STEAP4), a metalloreductase involved in iron and copper homeostasis, is thought to play a potentially important role in the cellular response to inflammatory stress. Genome-wide association studies have linked various mutations in STEAP4 with the development of metabolic disorders such as obesity, metabolic syndrome and type 2 diabetes. Several studies have shown that expression of Steap4 is modulated by inflammatory cytokines, hormones and other indicators of cellular stress and that STEAP4 may protect cells from damage, helping to maintain normal metaboli

SUBMITTER: Scarl RT 

PROVIDER: S-EPMC6166870 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature