High-risk human papillomavirus status and prognosis in invasive cervical cancer: A nationwide cohort study.

ABSTRACT:

Background

High-risk human papillomavirus (hrHPV) infection is established as the major cause of invasive cervical cancer (ICC). However, whether hrHPV status in the tumor is associated with subsequent prognosis of ICC is controversial. We aim to evaluate the association between tumor hrHPV status and ICC prognosis using national registers and comprehensive human papillomavirus (HPV) genotyping.

Methods and findings

In this nationwide population-based cohort study, we identified all ICC diagnosed in Sweden during the years 2002-2011 (4,254 confirmed cases), requested all archival formalin-fixed paraffin-embedded blocks, and performed HPV genotyping. Twenty out of 25 pathology biobanks agreed to the study, yielding a total of 2,845 confirmed cases with valid HPV results. Case

SUBMITTER: Lei J 

PROVIDER: S-EPMC6166926 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature