Body mass index may predict the response to ipilimumab in metastatic melanoma: An observational multi-centre study.

ABSTRACT:

Introduction

Immunotherapy is a well-established treatment option in patients with metastatic melanoma. However, biomarkers that can be used to predict a response in these patients have not yet been found, putting patients at risk of severe side effects.

Methods

In this retrospective analysis, we investigated the association between the body mass index and ipilimumab treatment response in patients with metastatic melanoma. Patients with metastatic melanoma who received a monotherapy of up to 4 doses of ipilimumab (3 mg/kg) every 3 weeks from 2011 to 2014 in three major hospitals in Austria were included. Patients were classified into two groups: normal group (BMI<25) and overweight group (BMI≥25).

Results

40 patients had a normal BMI, and 36 had a BMI above normal. Pa

SUBMITTER: Richtig G 

PROVIDER: S-EPMC6166940 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature