Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease.

ABSTRACT: The neuron navigator 2 (NAV2) gene is highly expressed in brain and involved in the nervous system development and may play a role in Alzheimer's disease (AD). We aimed to investigate the associations of 317 single-nucleotide polymorphisms (SNPs) in the NAV2 gene with the risk and age at onset (AAO) of AD using a family-based sample (1266 AD cases and 1279 healthy relatives). Association with the risk of AD was assessed using family-based association test -generalized estimating equations (FBAT- GEE) statistics while the association with AAO as a quantitative trait was evaluated using the FBAT-Wilcoxon statistic. Single marker analysis showed that 20 SNPs were significantly associated with the risk of AD (top SNP rs7112354 with p=8.46×10^-4) and 11 SNPs were associated with AAO (

SUBMITTER: Wang KS 

PROVIDER: S-EPMC6167010 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature