Investigation of SOSTDC1 gene in non-syndromic patients with supernumerary teeth.

ABSTRACT:

Background

The etiology of supernumerary teeth is still unclear however heredity is believed to be a major factor and this idea was supported by several case reports. Recently, a relationship between supernumerary tooth formation and deficiency of Uterine Sensitization Associated Gene-1 (Usag-1), a rat gene that is expressed in sensitized endometrium, was reported in mice. The human homolog gene for Usag-1, Sclerostin Domain Containing 1 (SOSTDC1), shows 85% identity with mouse Usag-1. The present study aimed to investigate SOSTDC1 coding regions in non-syndromic patients with one or more supernumerary teeth.

Material and methods

Twenty-five non-syndromic patients (21 male and 4 female) aged 5-15 years, with one or more supernumerary teeth were included in the study. Saliva

SUBMITTER: Arikan V 

PROVIDER: S-EPMC6167102 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature