Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease.

ABSTRACT:

Objective

The presence of psychosis in Alzheimer's disease denotes a phenotype with more rapid cognitive deterioration than in Alzheimer's disease without psychosis. Discovery of novel pharmacotherapies that engage therapeutic targets for prevention or treatment of Alzheimer's disease with psychosis would benefit from identifying the neurobiology of resilience to psychosis in Alzheimer's disease. The primary objective of this study was to determine whether alterations in the synaptic proteome were associated with resilience to psychotic symptoms in Alzheimer's disease and, if present, were independent of neuropathologic burden.

Method

Quantitative immunohistochemistry was used to measure multiple neuropathologies in dorsolateral prefrontal cortex from subjects with early and

SUBMITTER: Krivinko JM 

PROVIDER: S-EPMC6167138 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature