Ablation of proliferating neural stem cells during early life is sufficient to reduce adult hippocampal neurogenesis.

ABSTRACT: Environmental exposures during early life, but not during adolescence or adulthood, lead to persistent reductions in neurogenesis in the adult hippocampal dentate gyrus (DG). The mechanisms by which early life exposures lead to long-term deficits in neurogenesis remain unclear. Here, we investigated whether targeted ablation of dividing neural stem cells during early life is sufficient to produce long-term decreases in DG neurogenesis. Having previously found that the stem cell lineage is resistant to long-term effects of transient ablation of dividing stem cells during adolescence or adulthood (Kirshenbaum, Lieberman, Briner, Leonardo, & Dranovsky, ), we used a similar pharmacogenetic approach to target dividing neural stem cells for elimination during early life periods sensitive to envi

SUBMITTER: Youssef M 

PROVIDER: S-EPMC6167166 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature