Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum.

ABSTRACT:

Background

Cognitive and structural brain abnormalities range from mild to severe in psychosis. The relationships of specific cognitive functions to specific brain structures across the psychosis spectrum is less certain.

Methods

Participants (n = 678) with bipolar, schizoaffective, or schizophrenia psychoses and healthy control subjects were recruited via the Bipolar-Schizophrenia Network for Intermediate Phenotypes. The Schizo-Bipolar Scale was used to create a psychosis continuum (from purely affective to purely nonaffective). Canonical correlation between 14 cognitive measures and structural brain measures (gray matter volume, cortical thickness, cortical surface area, and local gyrification indices) for 68 neocortical regions yielded constructs that defined shared cogni

SUBMITTER: Rodrigue AL 

PROVIDER: S-EPMC6167203 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature