Efficacy and Safety of Initial Combination Therapy in Treatment-Naive Type 2 Diabetes Patients: A Systematic Review and Meta-analysis.

ABSTRACT:

Introduction

The aim of this study was to evaluate the efficacy and safety of initial combination therapy compared with monotherapy in drug-naïve type 2 diabetes patients.

Methods

MEDLINE, Embase and the Cochrane Central Register of Controlled Trials were searched for randomized clinical trials of initial combination therapy with hypoglycemic agents compared with monotherapy. Those which satisfied the search criteria were included in the meta-analysis. Weighted mean difference and relative risks were calculated.

Results

A total of 36 studies were included in the meta-analysis. Compared with metformin monotherapy, initial combination therapy with metformin plus another anti-diabetes drug exhibited significant reductions in glycated hemoglobin (HbA1c) (p < 0.001). Most

SUBMITTER: Cai X 

PROVIDER: S-EPMC6167297 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature