Higher Frequencies of Lymphocytes Expressing the Natural Killer Group 2D Receptor in Patients With Behcet Disease.

ABSTRACT: Behçet disease (BD) is an inflammatory systemic disease with a fluctuating course, which can affect the skin, eyes, central nervous system, musculoskeletal, gastrointestinal, and vascular systems. No laboratory tests are currently available for the diagnosis of BD and monitoring disease activity. Moreover there is a lack of knowledge on BD pathogenesis. This study focused on circulating Natural Killer (NK), NKT and T cells evaluated as CD3^neg CD56^pos, CD3^pos CD56^pos, and CD3^pos CD56^neg. Peripheral blood mononuclear cells (PBMCs) were collected from 38 BD patients and 20 healthy controls (HC). The frequencies of NK, NKT, and T cells expressing CD16, CD69, NKG2D, Nkp30, Nkp46, and NKG2A were assessed by flow cytometry. Cytotox

SUBMITTER: Bonacini M 

PROVIDER: S-EPMC6167483 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature