Temporal analysis of the autophagic and apoptotic phenotypes in Leishmania parasites.

ABSTRACT: The leishmaniases are worldwide neglected tropical diseases caused by parasitic protozoa of the Leishmania genus. Different stimuli induce Leishmania cell death, but the proteins involved remain poorly understood. Furthermore, confusion often appears between cell death and the cell survival process autophagy, whose phenotype is not clearly defined. In this article, we present a comprehensive and temporal analysis of the cellular events occurring during miltefosine-induced cell death and autophagy in L. major. We also provide a list of features in order to clearly identify apoptotic cells, autophagic cells and to distinguish both processes. Furthermore, we demonstrate that autophagy is followed by apoptosis in the absence of nutrients. Finally, we show that cells treate

SUBMITTER: Basmaciyan L 

PROVIDER: S-EPMC6167523 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature