¹⁸F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune Hepatitis.

ABSTRACT: Immune cell-mediated attack on the liver is a defining feature of autoimmune hepatitis and hepatic allograft rejection. Despite an assortment of diagnostic tools, invasive biopsies remain the only method for identifying immune cells in the liver. We evaluated whether PET imaging with radiotracers that quantify immune activation (¹⁸F-FDG and ¹⁸F-1-(2'-deoxy-2'-fluoro-arabinofuranosyl)cytosine [¹⁸F-FAC]) and hepatocyte biology (¹⁸F-2-deoxy-2-fluoroarabinose [¹⁸F-DFA]) can visualize and quantify liver-infiltrating immune cells and hepatocyte inflammation, respectively, in a preclinical model of autoimmune hepatitis. Methods: Mice treated with concanavalin A (ConA) to induce a model of autoimmune hepatitis or vehicle were imaged wit

SUBMITTER: Salas JR 

PROVIDER: S-EPMC6167535 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature