Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome.

ABSTRACT:

Background

Matrix Gla Protein (MGP) is a potent inhibitor of ectopic calcification and modulates bone morphogenesis. Little is known about MGP expression or function in kidney.

Methods

We investigated renal MGP expression in Sprague-Dawley rats after 5/6 nephrectomy (5/6 Nx) and in human kidney biopsies in the Nephrotic Syndrome Study Network (NEPTUNE) cohort. We analyzed associations between glomerular (n = 182) and tubulointerstitial (TI) (n = 219) MGP mRNA levels and the disease activity/histologic features in NEPTUNE patients. Additionally, uncarboxylated and carboxylated MGP (ucMGP and cMGP, respectively) were localized by immunohistochemistry and quantitated in kidney tissues of patients at different stages of CKD (n = 18).

Results

Renal MGP expression was incre

SUBMITTER: Miyata KN 

PROVIDER: S-EPMC6167754 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature