Molecular signature of response to preoperative radiotherapy in locally advanced breast cancer.

ABSTRACT:

Background

Radiation therapy is an indispensable part of various treatment modalities for breast cancer. Specifically, for non-inflammatory locally advanced breast cancer (LABC) patients, preoperative radiotherapy (pRT) is currently indicated as a second line therapy in the event of lack of response to neoadjuvant chemotherapy. Still approximately one third of patients fails to respond favourably to pRT. The aim of this study was to explore molecular mechanisms underlying differential response to radiotherapy (RT) to identify predictive biomarkers and potential targets for increasing radiosensitivity.

Methods

The study was based on a cohort of 134 LABC patients, treated at the Institute of Oncology and Radiology of Serbia (IORS) with pRT, without previous or concomitant syst

SUBMITTER: Tanic M 

PROVIDER: S-EPMC6167820 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature