Tinospora cordifolia as a potential neuroregenerative candidate against glutamate induced excitotoxicity: an in vitro perspective.

ABSTRACT:

Background

Glutamate, the major excitatory neurotransmitter of CNS acts as a neurotoxin at higher concentrations. Prolonged activation of glutamate receptors results in progressive neuronal damage by aggravating calcium influx, inducing mitochondrial damage and oxidative stress. Excitotoxic cell death is associated with the pathogenesis of various neurodegenerative disorders such as trauma, brain injury and neurodegenerative diseases. The current study was designed to investigate the neuroprotective and neuroregenerative potential of Tinospora cordifolia against glutamate-induced excitotoxicity using primary cerebellar neuronal cultures as a model system.

Methods

Monosodium salt of glutamate was used to induce neurotoxic injury in primary cerebellar neurons. Four extracts in

SUBMITTER: Sharma A 

PROVIDER: S-EPMC6167833 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature