Protective effects and mechanisms of Terminalia catappa L. methenolic extract on hydrogen-peroxide-induced oxidative stress in human skin fibroblasts.

ABSTRACT:

Background

Oxidative stress plays a crucial role in aging-related phenomenon, including skin aging and photoaging. This study investigated the protective role and possible mechanism of Terminalia catappa L. methanolic extract (TCE) in human fibroblasts (Hs68) against hydrogen peroxide (H₂O₂)-induced oxidative damage.

Methods

Various in vitro antioxidant assays were performed in this study. The effect and mechanisms of TCE on oxidative stress-induced oxidative damage were studied by using western blotting.

Results

The IC₅₀ of TCE was 8.2 μg/mL for 1,1-diphenyl-2-picrylhydrazyl radical scavenging, 20.7 μg/mL for superoxide anion radical scavenging, 173.0 μg/mL for H₂O₂ scavenging, 44.8 μg/mL for hydroxyl radical sca

SUBMITTER: Huang YH 

PROVIDER: S-EPMC6167875 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature