Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance.

ABSTRACT:

Background

Increased collagen expression and deposition are associated with cancer progression and poor prognosis in breast cancer patients. However, function and regulation of membrane-associated collagen in breast cancer have not been determined. Collagen XIII is a type II transmembrane protein within the collagen superfamily. Experiments in tissue culture and knockout mouse models show that collagen XIII is involved in cell adhesion and differentiation of certain cell types. In the present study, we determined roles of collagen XIII in breast cancer progression and metastasis.

Methods

We analyzed the association of collagen XIII expression with breast cancer development and metastasis using published gene expression profiles generated from human breast cancer tissues. Uti

SUBMITTER: Zhang H 

PROVIDER: S-EPMC6167877 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature