Outcome measures in clinical trials of treatments for acute severe haemorrhage.

ABSTRACT:

Background

Acute severe haemorrhage is a common complication of injury, childbirth, surgery, gastrointestinal pathologies and other medical conditions. Bleeding is a major cause of death, but patients also die from non-bleeding causes, the frequency of which varies by the site of haemorrhage and between populations. Because patients can bleed to death within hours, established interventions inevitably take priority over randomisation into a trial. These circumstances raise challenges in selecting appropriate outcome measures for clinical trials of haemostatic interventions.

Main body

We use data from three large randomised controlled trials in acute severe haemorrhage (CRASH-2, WOMAN and HALT-IT) to explore the strengths and limitations of outcome measures commonly used in t

SUBMITTER: Brenner A 

PROVIDER: S-EPMC6167881 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature