Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands.

ABSTRACT:

Background

The Open Targets Platform integrates different data sources in order to facilitate identification of potential therapeutic drug targets to treat human diseases. It currently provides evidence for nearly 2.6 million potential target-disease pairs. G-protein coupled receptors are a drug target class of high interest because of the number of successful drugs being developed against them over many years. Here we describe a systematic approach utilizing the Open Targets Platform data to uncover and prioritize potential new disease indications for the G-protein coupled receptors and their ligands.

Results

Utilizing the data available in the Open Targets platform, potential G-protein coupled receptor and endogenous ligand disease association pairs were systematically ide

SUBMITTER: Freudenberg JM 

PROVIDER: S-EPMC6167889 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature