The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder.

ABSTRACT:

Background

Histological evidence suggests that autism spectrum disorder (ASD) is accompanied by a reduced integrity of the grey-white matter boundary. This has also recently been confirmed by a structural neuroimaging study in vivo reporting significantly reduced grey-white matter tissue contrast (GWC) in adult individuals (18-42 years of age) with ASD relative to typically developing (TD) controls. However, it remains unknown whether the neuroanatomical differences in ASD at the grey-white matter boundary are stable across development or are age-dependent.

Methods

Here, we examined differences in the neurodevelopmental trajectories of GWC in a cross-sectional sample of 77 male ASD individuals and 76 typically developing (TD) controls across childhood and early adulthood (fr

SUBMITTER: Mann C 

PROVIDER: S-EPMC6167902 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature